1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester
NOD-IN-1
CAS: 132819-92-2
Molecular Formula: C18H17NO4S
1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester - Names and Identifiers
1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester - Physico-chemical Properties
| Molecular Formula | C18H17NO4S |
| Molar Mass | 343.4 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 98-99 °C |
| Boling Point | 523.3±52.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Storage Condition | 2-8°C |
| In vitro study | NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC 50 (NOD1)=5.74 μM; IC 50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets. |
1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.912 ml | 14.56 ml | 29.121 ml |
| 5 mM | 0.582 ml | 2.912 ml | 5.824 ml |
| 10 mM | 0.291 ml | 1.456 ml | 2.912 ml |
| 5 mM | 0.058 ml | 0.291 ml | 0.582 ml |
Last Update：2024-01-02 23:10:35
1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester - Reference Information
| biological activity | NOD-IN-1 (MDK19922, Compound 4) it is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2, corresponding to IC50 values of 5.74 μm and 6.45 μm, respectively. |
| Target | IC50: 5.74 μm (NOD1), 6.45 μm (NOD2) |
Last Update：2024-04-09 20:49:11
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Product Name: NOD-IN-1 Visit Supplier Webpage Request for quotationCAS: 132819-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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